5/18/2025
Last update
5/18/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.9
USERS' SCORE
Good
Based on 9 Reviews
8.5
Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
5,000 mcg
208,333%
Top Medical Research Studies
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
Read More
8
We explored the relationship between nitrous oxide abuse and cerebral venous thrombosis in a 19-year-old female patient. After using nitrous oxide, her vitamin B12 levels dropped significantly, leading to increased homocysteine, a marker associated with clotting issues.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Read More
8
We explored a compelling case of pernicious anemia that led to a rare presentation of disseminated intravascular coagulation (DIC). The patient, a 63-year-old woman, faced severe anemia and a significant vitamin B12 deficiency.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
Read More
Most Useful Reviews
10
Effective treatment
4 people found this helpful
It does its job! In two months, my B12 level rose from 200 to 1400 with this medication, and improvements in other blood parameters are evident: my haemoglobin has increased, and my red blood cells have improved. I am very pleased with the results. According to my doctor, a temporary excess of vitamin is not concerning; anything excessive will dissipate after two months. Therefore, I suggested having the B12 test again after two months post-discontinuation to check levels.
Read More
9
Rapid B12 increase
4 people found this helpful
A very quick method to elevate B12 levels in the blood!
Read More
9
Vegetarian friendly
4 people found this helpful
As a vegetarian for over nine years, I've struggled with dairy but manage fine with eggs. I have been consistently taking this supplement, and after my doctor checked my blood levels this summer, my B12 was precisely where it should be. I plan to keep using this product alongside my other supplements.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.9
- All Researches
9
This case report examined a 14-year-old girl who experienced cerebral venous thrombosis alongside high homocysteine levels due to a unique genetic mutation at the MTHFR locus.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
Read More
9
We explored a unique case involving a 49-year-old woman who experienced postprandial hypoglycemia following Roux-en-Y gastric bypass surgery. While hypoglycemia is uncommon, her medical history of mesenteric thrombosis and prior anticoagulation treatment contributed to her condition.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
Read More
9
We explored how elevated homocysteine levels, termed hyperhomocysteinemia (HHcy), impact patients with acute brain injuries in neurocritical care. Our systematic review of 33 studies revealed that HHcy is an independent risk factor for various brain injuries and a marker of poor prognosis.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Read More
9
We encountered a compelling case that sheds light on the relationship between vitamin B-12 deficiency and a condition known as pseudo-thrombotic microangiopathic anemia. This condition often mimics more severe blood disorders requiring aggressive treatments. However, during this case, we observed that addressing the deficiency with vitamin B-12 injections led to a significant improvement.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Read More
8
We examined a case involving Biermer's disease, where a 56-year-old man experienced neurological and cardiovascular complications. Despite the serious symptoms of melena, memory issues, and swelling in the leg, he was diagnosed with deep vein thrombosis and severe vitamin B12 deficiency.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
10
Effective treatment
4 people found this helpful
It does its job! In two months, my B12 level rose from 200 to 1400 with this medication, and improvements in other blood parameters are evident: my haemoglobin has increased, and my red blood cells have improved. I am very pleased with the results. According to my doctor, a temporary excess of vitamin is not concerning; anything excessive will dissipate after two months. Therefore, I suggested having the B12 test again after two months post-discontinuation to check levels.
Read More
9
Rapid B12 increase
4 people found this helpful
A very quick method to elevate B12 levels in the blood!
Read More
9
Vegetarian friendly
4 people found this helpful
As a vegetarian for over nine years, I've struggled with dairy but manage fine with eggs. I have been consistently taking this supplement, and after my doctor checked my blood levels this summer, my B12 was precisely where it should be. I plan to keep using this product alongside my other supplements.
Read More
10
Effective B12 boost
3 people found this helpful
Blood tests confirm its efficacy. I began taking it due to low B12 levels, and after doubling my dose, my subsequent blood test showed that my B12 levels were excessively high! Remarkably effective!
Read More
7.5
Mood enhancement
3 people found this helpful
An excellent form of B12! My mood has improved significantly, and I feel invigorated. I paired this with folic acid due to previously high homocysteine and low B12 levels. Vitamin B12 plays a crucial role in blood cell development; it is especially vital for those on a vegan diet.
Read More
Frequently Asked Questions
10
Effective treatment
4 people found this helpful
It does its job! In two months, my B12 level rose from 200 to 1400 with this medication, and improvements in other blood parameters are evident: my haemoglobin has increased, and my red blood cells have improved. I am very pleased with the results. According to my doctor, a temporary excess of vitamin is not concerning; anything excessive will dissipate after two months. Therefore, I suggested having the B12 test again after two months post-discontinuation to check levels.
9
Rapid B12 increase
4 people found this helpful
A very quick method to elevate B12 levels in the blood!
9
Health improvement
4 people found this helpful
After discovering my MTHFR mutation, I had to check my B12 levels. As a vegetarian, my results were low, leading me to discard the doctor's prescribed supplements in favour of this product. My blood now shows normal B12 levels, and I feel tremendously better—plus they taste delightful!
9
Vegetarian friendly
4 people found this helpful
As a vegetarian for over nine years, I've struggled with dairy but manage fine with eggs. I have been consistently taking this supplement, and after my doctor checked my blood levels this summer, my B12 was precisely where it should be. I plan to keep using this product alongside my other supplements.
7.5
Mood enhancement
3 people found this helpful
An excellent form of B12! My mood has improved significantly, and I feel invigorated. I paired this with folic acid due to previously high homocysteine and low B12 levels. Vitamin B12 plays a crucial role in blood cell development; it is especially vital for those on a vegan diet.
10
Effective B12 boost
3 people found this helpful
Blood tests confirm its efficacy. I began taking it due to low B12 levels, and after doubling my dose, my subsequent blood test showed that my B12 levels were excessively high! Remarkably effective!
7.5
Injection alternative
1 people found this helpful
This is a simple substitute for B12 injections. I used this product instead of injections and achieved the same blood values.
7
We explored the relationship between Vitamin B12 deficiency and cerebral venous sinus thrombosis (CVST) through a case series involving three patients. Each presented with headaches, and two experienced visual disturbances, which led to evaluations revealing CVST and high homocysteine levels, a known risk factor for clots. Notably, two patients had very low Vitamin B12 levels. All received anticoagulation treatment along with Vitamin B supplements and showed positive responses, with imaging confirming the resolution of thrombosis in two cases. This suggests an important connection between B12 levels and clot formation, particularly in vegetarians.
8
We explored the relationship between nitrous oxide abuse and cerebral venous thrombosis in a 19-year-old female patient. After using nitrous oxide, her vitamin B12 levels dropped significantly, leading to increased homocysteine, a marker associated with clotting issues.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
9
We explored a unique case involving a 49-year-old woman who experienced postprandial hypoglycemia following Roux-en-Y gastric bypass surgery. While hypoglycemia is uncommon, her medical history of mesenteric thrombosis and prior anticoagulation treatment contributed to her condition.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
8
We examined a case involving Biermer's disease, where a 56-year-old man experienced neurological and cardiovascular complications. Despite the serious symptoms of melena, memory issues, and swelling in the leg, he was diagnosed with deep vein thrombosis and severe vitamin B12 deficiency.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
References
- Bizouard T, Caplette C, Duval D, Savary D, Douillet D. Right iliac deep vein thrombosis and pulmonary embolism associated with recreational nitrous oxide: a case report. Int J Emerg Med. 2024;17:169. 10.1186/s12245-024-00689-z
- Turcu-Stiolica A, Naidin MS, Halmagean S, Ionescu AM, Pirici I. The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania. Diagnostics (Basel). 2024;14. 10.3390/diagnostics14151609
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. 10.4103/aam.aam_138_23
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. 10.7759/cureus.58601
- Khaliq L, Kabir KF, Pyai K, Hadid T, Collins-Hamel B. A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis. Cureus. 2023;15:e42908. 10.7759/cureus.42908
- Banjongjit A, Sutamnartpong P, Mahanupap P, Phanachet P, Thanakitcharu S. Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review. Cureus. 2023;15:e41428. 10.7759/cureus.41428
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. 10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. 10.3892/mi.2022.45
- Coelho T, Freitas A, Carmona Alexandrino H, Pinto S. Roux-en-Y Gastric Bypass Surgery Leading to Postprandial Hypoglycemia: A Case Report. Cureus. 2022;14:e32265. 10.7759/cureus.32265
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. 10.1177/19714009221147224
- Aboona MB, Rapaich L, Etman A, Thomas SW. A Rare Presentation of Pernicious Anemia Manifesting as Disseminated Intravascular Coagulation. J Med Cases. 2022;13:557. 10.14740/jmc4020
- Lauretta MP, Melotti RM, Sangermano C, George AM, Badenes R, et al. Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence. J Clin Med. 2022;11. 10.3390/jcm11020394
- Mohamed Yile MEH, Berteau E, Ramdani N, Mouyen T, Ferrier N. Uncommon Thromboembolic Events in Young Adults: A Rare Cause Uncovered. Cureus. 2025;17:e76962. 10.7759/cureus.76962
- Landry I, Chowdhury T, Hussein S, Thomas L. Life-Threatening Microangiopathy or Vitamin Deficiency: A Case Report of the Clinical Manifestations of Pseudo-Thrombotic Microangiopathic Anemia. Cureus. 2021;13:e20228. 10.7759/cureus.20228
